Vaccine

19-26 years

27-49 years

50-64 years

65+ years

Contraindications

Precautions

COVID-19

2- or 3- dose primary series and booster

History of a severe allergic reaction or a known diagnosed allergy to a component of the COVID-19 vaccine†

History of anaphylaxis, moderate or severe acute illness, with or without fever, myocarditis, or a non-severe, immediate allergic reaction after a dose.

Influenza inactivated (IIV4)

1 dose annually

Severe allergic reaction after previous dose of any influenza vaccine or to any vaccine component (excluding egg)

Guillain-Barré syndrome (GBS) within 6 weeks after a previous dose. Moderate or severe acute illness with or without fever

Influenza live attenuated

1 dose annually

Severe allergic reaction, anatomic or functional asplenia, immunocompromised due to any cause, close contacts or caregivers of severely immunosuppressed persons,, pregnancy, Cochlear implant.

Guillain-Barré syndrome (GBS) within 6 weeks after a previous dose. Asthma in persons aged 5 years or older. Persons with underlying medical conditions. Moderate or severe acute illness with or without fever.

Tetanus, diphtheria pertussis

1 dose Tdap, then Td or Tdap booster every 10 years

Severe allergic reaction after a previous dose or to a vaccine component. For Tdap only: Encephalopathy not attributable to another identifiable cause, within 7 days of administration of previous dose of DTP, DTaP, or Tdap 

Guillain-Barré syndrome (GBS) within 6 weeks after a previous dose. History of Arthus-type hypersensitivity reactions. oderate or severe acute illness with or without fever For Tdap only: Progressive or unstable neurological disorder, uncontrolled seizures, or progressive encephalopathy.

Measles, mumps, rubella

1 or 2 doses if born in 1957 or later

Severe allergic reaction. Severe immunodeficiency. Pregnancy. Family history of altered immunocompetence. 

Recent (≤11 months) receipt of antibody-containing blood product. History of thrombocytopenia or thrombocytopenic purpura. Moderate or severe acute illness with or without fever

Varicella

2 doses if born in 1980 or later

2 doses

Severe allergic reaction. Severe immunodeficiency. Pregnancy. Family history of altered immunocompetence. 

Recent (≤11 months) receipt of antibody-containing blood product. Receipt of specific antiviral drugs 24 hours before vaccination. Use of aspirin. Moderate or severe acute illness with or without fever

Zoster

2 doses for immunocompromising conditions

2 doses

Severe allergic reaction after a previous dose.

Moderate or severe acute illness with or without fever. Current herpes zoster infection

Human papillomavirus

2 or 3 doses

27 through 45 years

Severe allergic reaction after a previous dose. Pregnancy: HPV vaccination not recommended 

Moderate or severe acute illness with or without fever

Pneumococcal

1 dose PCV15 followed by PPSV23 or 1 dose PCV20

Severe allergic reaction after a previous dose. Severe allergic reaction to any diphtheria-toxoid–containing vaccine.

Moderate or severe acute illness with or without fever

Hepatitis A

2, 3, or 4 doses depending on vaccine

Severe allergic reaction after a previous dose, including neomycin

Moderate or severe acute illness with or without fever

Hepatitis B

2, 3, or 4 doses depending on vaccine or condition

Severe allergic reaction after a previous dose, including yeast.Pregnancy: Heplisav-B and PreHevbrio are not recommended.

Moderate or severe acute illness with or without fever

Meningococcal A, C, W, Y

1 or 2 doses depending on indication

Severe allergic reaction after a previous dose. 

Moderate or severe acute illness with or without fever

Meningococcal B

19 through 23 years

2 or 3 doses depending on vaccine and indication, see notes for booster recommendations

Severe allergic reaction after a previous dose.

Pregnancy. Latex sensitivity. Moderate or severe acute illness with or without fever

Haemophilus Influenza

1 or 3 doses depending on indication

Severe allergic reaction after a previous dose. History of severe allergic reaction to dry natural latex 

Moderate or severe acute illness with or without fever

Source: Centers for Disease Control and Prevention