If you have been prescribed at least two antidepressants in the past and still experience the symptoms, including suicidal thoughts†, you probably have a condition known as treatment-resistant depression (TRD). Spravato is an FDA-approved nasal spray treatment for adults‡ who have not tried two or more oral antidepressants and have not achieved improvement.

Spravato is available only through a restricted distribution program called the Spravato ® REMS. Wilmington Mental Health is a certified Spravato® treatment center that follows protocols for handling Schedule III medication in accordance with federal, state, and local regulations. Referrals for Spravato must be coordinated with your primary care provider for psychiatric medications.

Depression is a complicated condition that involves not only serotonin deficiency or environmental changes; but the way it manifests in people who do not respond well to antidepressants is more complicated. Spravato helps the brain by reversing the changes produced by depression. It increases glutamate production in the brain, exciting certain brain cells in charge of learning functions and memory, and making the brain become more comfortable with the new state.