If you have been prescribed at least two antidepressants in the past and still experience the
symptoms, including suicidal thoughts†, you probably have a condition known as
treatment-resistant depression (TRD). Spravato is an FDA-approved nasal spray treatment for
adults‡ who have not tried two or more oral antidepressants and have not achieved improvement.
Spravato is available only through a restricted distribution program called the Spravato ® REMS.
Wilmington Mental Health is a certified Spravato® treatment center that follows protocols for
handling Schedule III medication in accordance with federal, state, and local regulations.
Referrals for Spravato must be coordinated with your primary care provider for psychiatric